peginesatide   Click here for help

GtoPdb Ligand ID: 7447

Synonyms: AF37702 | Hematide® | Omontys®
Approved drug
peginesatide is an approved drug (FDA (2012))
Compound class: Peptide
Comment: Peginesatide is a PEGylated functional analogue of erythropoietin.
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Bioactivity Comments
Initial studies in humans demonstrate that peginesatide increases haemoglobin (ie stimulates red blood cell production) in patients with chronic kidney disease [2].
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Eythropoietin receptor Primary target of this compound Hs Agonist Agonist 10.4 pIC50 - 1
pIC50 10.4 (IC50 3.7x10-11 M) [1]