Ligand id: 7529

Name: SGC-CBP30

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 65.55
Molecular weight 508.22
XLogP 5
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In vitro, treatment of primary human cells with CBP30 reduces immune cell production of IL-17A and other proinflammatory cytokines. CBP30 exposure also inhibits IL-17A secretion by donor derived Th17 cells, and from the same cells from patients with ankylosing spondylitis or psoriatic arthritis [2].
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
E1A binding protein p300 Hs Inhibitor Inhibition 7.4 pIC50 - 1
pIC50 7.4 (IC50 3.8x10-8 M) [1]
CREB binding protein Hs Inhibitor Inhibition 7.2 pIC50 - 1
pIC50 7.2 (IC50 6.9x10-8 M) [1]