Synonyms: AZ-13337019 | AZ13337019 | Movantik® | Moventig® | NKTR-118
naloxegol is an approved drug (EMA & FDA (2014))
Compound class:
Synthetic organic
Comment: Naloxegol is a PEGylated version of naloxol (α-naloxol PubChem CID 5492271; β-naloxol PubChem CID 5492293). PEGylation reduces the compound's ability to cross the blood-brain barrier, therefore restricting CNS penetration. Naloxegol is termed a peripherally acting μ-opioid receptor antagonist, or PAMORA. The synonyms suffixed with "oxalate " map to the salt as PubChem CID 56959086
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Bioactivity Comments |
Nektar Therapeutics report a Ki of 33.8nM for this compound at the μ-opioid receptor, although these results have not been published. See Nektar Therapeutics Poster 28, Eldon et al, 2007 which was presented at the American Academy of Pain Management 18th Annual Clinical Meeting; September 27–30, 2007; Las Vegas, NV. |