dupilumab   Click here for help

GtoPdb Ligand ID: 7574

Synonyms: Dupixent® | REGN668 | SAR231893
Approved drug Immunopharmacology Ligand
dupilumab is an approved drug (EMA & FDA (2017))
Compound class: Antibody
Comment: Dupilumab is fully human monoclonal antibody against the α subunit of the IL4 receptor.
Peptide sequences for this antibody are available from its IMGT/mAb-db record. Dupilumab was produced using Regeneron's genetically engineered VelocImmune® mice which have humanized immunoglobulin gene loci and produce human:mouse hybrid antibodies that can rapidly be converted to fully human antibodies [3].
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Bioactivity Comments
Affinity data in the table below is taken from patent US7608693 [2], using antibody clone H4H098P as a representative example of the embodiment of the patent. The clone becoming dupilumab is not reported.
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-4 receptor subunit α Primary target of this compound Hs Antibody Binding 11.1 pIC50 - 2
pIC50 11.1 (IC50 8.8x10-12 M) [2]
Description: Value derived from an ELISA-based solution competition assay.