andexanet alfa

Ligand id: 7576

Name: andexanet alfa

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Bioactivity Comments
In enzyme assays using purified human plasma factor Xa, andexanet alfa reverses the inhibitory activity of betrixaban, rivaroxaban and apixaban inhibition on factor Xa activity with KDs of 0.53, 1.53 and 0.58nM respectively [1]
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
apixaban Hs Inhibitor Binding 9.2 pKd - 1
pKd 9.2 (Kd 5.8x10-10 M) [1]
Description: Enzyme assays using purified human plasma fXa, inhibited by apixaban.
rivaroxaban Hs Inhibitor Binding 8.8 pKd - 1
pKd 8.8 (Kd 1.53x10-9 M) [1]
Description: Enzyme assays using purified human plasma fXa, inhibited by rivaroxaban.