lesogaberan

Ligand id: 7705

Name: lesogaberan

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 86.79
Molecular weight 141.04
XLogP -1.12
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Since the orthosteric binding site of the GABAB receptor resides in the GABBR1 subunit we have mapped the binding interaction of lesogaberan to this subunit. Pending publication, the data presented here is derived from the compound's record in AstaZeneca's Open Innovation Pharmacology Toolbox [1].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
GABAB1 Hs Agonist Agonist 8.1 pEC50 - 1
pEC50 8.1 (EC50 8x10-9 M) [1]