mavrilimumab   Click here for help

GtoPdb Ligand ID: 7785

Synonyms: CAM-3001 | KPL-301
Immunopharmacology Ligand
Compound class: Antibody
Comment: Mavrilimumab targets CSF2RA (aka GM-CSFRα).
Peptide sequences for this antibody are available from its IMGT/mAb-DB record. Peptide sequence analysis identifies mavrilimumab as antibody 6 in patent US8263075 [2].
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Bioactivity Comments
Results presented in patent US8263075 [2] show that mavrilimumab (antibody 6) has potent effects in biological assays, including inhibition of GM-CSF-induced proliferation of TF-1 ( human erythroleukemic) cells and activity in GM-CSF-induced shape change assays using human granulocytes.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
GM-CSF receptor, α subunit Primary target of this compound Hs Antibody Binding 9.9 pIC50 - 2
pIC50 9.9 (IC50 1.39x10-10 M) [2]