depatuxizumab mafodotin   Click here for help

GtoPdb Ligand ID: 7970

Synonyms: ABT-414
Compound class: Antibody
Comment: Depatuxizumab mafodotin (ABT-414) is an antibody-drug conjugate (ADC), which targets a unique tumour-specific EGFR epitope in some cancer cells [5]. The antibody portion recognises EGFR in glioblastoma cells with EGFR gene amplification or expressing the truncated Δ2-7 EGFR mutant (aka EGFRvIII) [2-3]. The antibody is linked to the cytotoxic agent, monomethyl auristatin F (MMAF; PubChem CID 56841603) (information derived from Phillips et al. (2013) [4] and Abbvie's webpage for oncology pipeline compounds and references therein [1].
Bioactivity Comments
The antibody binds Δ2-7 EGFR with an affinity of 1nM [3]. It exhibits minimal reactivity to EGFR in normal tissue [5].