depatuxizumab mafodotin   Click here for help

GtoPdb Ligand ID: 7970

Synonyms: ABT-414
Compound class: Antibody
Comment: Depatuxizumab mafodotin (ABT-414) is an antibody-drug conjugate (ADC), which targets a unique tumour-specific EGFR epitope in some cancer cells [5]. The antibody portion recognises EGFR in glioblastoma cells with EGFR gene amplification or expressing the truncated Δ2-7 EGFR mutant (aka EGFRvIII) [2-3]. The antibody is linked to the cytotoxic agent, monomethyl auristatin F (MMAF; PubChem CID 56841603) (information derived from Phillips et al. (2013) [4] and Abbvie's webpage for oncology pipeline compounds and references therein [1].
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
10263 depatuxizumab mafodotin
Synonyms Click here for help
Database Links Click here for help
GtoPdb PubChem SID 249565653
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