NVP-AEW541   Click here for help

GtoPdb Ligand ID: 8067

Synonyms: AEW541 | NVP AEW541 | NVP-AEW 541 | NVP-AEW541-A
Compound class: Synthetic organic
Comment: NVP-AEW541 is a potent and selective inhibitor of the receptor tyrosine kinase, insulin-like growth factor I receptor (IGF1R) [1]. It was tested in preclinical studies.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 69.2
Molecular weight 439.24
XLogP 5.08
No. Lipinski's rules broken 1
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Canonical SMILES Nc1ncnc2c1c(cn2C1CC(C1)CN1CCC1)c1cccc(c1)OCc1ccccc1
Isomeric SMILES Nc1ncnc2c1c(cn2C1CC(C1)CN1CCC1)c1cccc(c1)OCc1ccccc1
InChI InChI=1S/C27H29N5O/c28-26-25-24(21-8-4-9-23(14-21)33-17-19-6-2-1-3-7-19)16-32(27(25)30-18-29-26)22-12-20(13-22)15-31-10-5-11-31/h1-4,6-9,14,16,18,20,22H,5,10-13,15,17H2,(H2,28,29,30)
Bioactivity Comments
NVP-AEW541 inhibits IGF1R signalling in in vivo tumour models and reduces the growth of IGF-IR-driven fibrosarcomas [1], indicating its therapeutic potential.
ERBB2 (aka HER2) is a known off-target of this compound.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Insulin-like growth factor I receptor Primary target of this compound Hs Inhibitor Inhibition 9.4 pIC50 - 1
pIC50 9.4 (IC50 4x10-10 M) [1]