- Advanced search
- Immuno Portal
- Malaria Portal
Compound class: Synthetic organic
Comment: MSC2032964A is a hit compound identified in . MSC2032964A is an inhibitor of mitogen-activated protein kinase kinase kinase 5 (MAP3K5, aka ASK1). It was tested in preclinical studies.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|MSC2032964A attenuates neuroinflammation in experimental autoimmune encephalomyelitis (EAE) . Additional experimental results suggest that targeting the TLR-ASK1-p38 pathway in glial cells may represent a novel mechanism via which autoimmune demyelinating disorders such as multiple sclerosis might be treatable .
A panel of 210 kinases were tested and results are available in Supplementary table S1 from . This screening panel indicates that casein kinase 1 (CK1) and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) are off-targets for MSC2032964A.
|Selectivity at enzymes|
|Key to terms and symbols||Click column headers to sort|