bimagrumab   Click here for help

GtoPdb Ligand ID: 8086

Synonyms: BYM-338 | BYM338
Compound class: Antibody
Comment: Bimagrumab is an investigational monoclonal antibody designed to treat the pathological muscle loss and weakness caused by the inflammatory muscle depleting disease, sporadic inclusion body myositis (sIBM).
Click here for help
Bioactivity Comments
Bimagrumab inhibits myostatin binding to ACVR2B, thereby blocking myostatin-induced signalling as measured by a Smad dependent reporter gene assay [2].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
activin A receptor type 2B Primary target of this compound Hs Antibody Binding 11.8 pKd - 2
pKd 11.8 (Kd 1.73x10-12 M) [2]
Description: Binding affinity of clone MOR08159
activin A receptor type 2A Hs Antibody Binding 9.4 pKd - 2
pKd 9.4 (Kd 4.34x10-10 M) [2]
Description: Binding affinity of clone MOR08159