bimagrumab

Ligand id: 8086

Name: bimagrumab

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Bimagrumab inhibits myostatin binding to ACVR2B, thereby blocking myostatin-induced signalling as measured by a Smad dependent reporter gene assay [2].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
activin A receptor type 2B Hs Antibody Binding 11.8 pKd - 2
pKd 11.8 (Kd 1.73x10-12 M) [2]
Description: Binding affinity of clone MOR08159
activin A receptor type 2A Hs Antibody Binding 9.4 pKd - 2
pKd 9.4 (Kd 4.34x10-10 M) [2]
Description: Binding affinity of clone MOR08159