necitumumab   Click here for help

GtoPdb Ligand ID: 8090

Synonyms: 11F8 | IMC-11F8 | LY3012211 | Portrazza®
Approved drug
necitumumab is an approved drug (FDA (2015), EMA (2016))
Compound class: Antibody
Comment: Necitumumab is a monoclonal antibody with clinical antineoplastic action [1-3].
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record.
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Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
epidermal growth factor receptor Primary target of this compound Hs Antibody Binding 9.5 pKd - 1
pKd 9.5 (Kd 3.2x10-10 M) [1]
Description: Binding affinity of whole IMC-11F8 IgG using BIAcore sensor technology.