necitumumab   Click here for help

GtoPdb Ligand ID: 8090

Synonyms: 11F8 | IMC-11F8 | LY3012211 | Portrazza®
Approved drug
necitumumab is an approved drug (FDA (2015), EMA (2016))
Compound class: Antibody
Comment: Necitumumab is a monoclonal antibody with clinical antineoplastic action [1-3].
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record.
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No information available.
Summary of Clinical Use Click here for help
Necitumumab is being investigated in several clinical trials at various stages of development: solid tumours (Phase 1), metastatic colorectal cancer (Phase 2) and non-small-cell lung cancer (Phase 3, NCT00981058, for squamous cell NSCLC and NCT00982111, for nonsquamous NSCLC). Click here to link to's complete listing of registered necitumumab trials.
In November 2015, the US FDA approved necitumumab (in combination with the chemotherapeutics gemcitabine and cisplatin) to treat patients with advanced (metastatic) squamous non-small cell lung cancer (NSCLC) who have not previously received anti-lung cancer therapy.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Necitumumab targets the epidermal growth factor receptor (EGFR), inhibiting the receptor's tyrosine kinase activity and inhibiting growth of EGFR-expressing tumour cells [1].
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