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|No information available.|
|Summary of Clinical Use|
|Necitumumab is being investigated in several clinical trials at various stages of development: solid tumours (Phase I), metastatic colorectal cancer (Phase II) and non-small-cell lung cancer (Phase III, NCT00981058, for squamous cell NSCLC and NCT00982111, for nonsquamous NSCLC). Click here to link to ClinicalTrials.gov's complete listing of registered necitumumab trials.
In November 2015, the US FDA approved necitumumab (in combination with the chemotherapeutics gemcitabine and cisplatin) to treat patients with advanced (metastatic) squamous non-small cell lung cancer (NSCLC) who have not previously received anti-lung cancer therapy.
|Mechanism Of Action and Pharmacodynamic Effects|
|Necitumumab targets the epidermal growth factor receptor (EGFR), inhibiting the receptor's tyrosine kinase activity and inhibiting growth of EGFR-expressing tumour cells .|
For extended ADME data see the following:
Electronic Medicines Compendium (eMC)
European Medicines Agency (EMA)