IOX1   

GtoPdb Ligand ID: 8230

Compound class: Synthetic organic
Comment: IOX1 is a cell-permeable, broad-spectrum 2-oxoglutarate oxygenase inhibitor [1]. This is a compound from the Structural Genomics Consortium's (SGC) Epigenetics Probes Collection.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 70.42
Molecular weight 189.04
XLogP 1.33
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES OC(=O)c1ccc(c2c1cccn2)O
Isomeric SMILES OC(=O)c1ccc(c2c1cccn2)O
InChI InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
InChI Key JGRPKOGHYBAVMW-UHFFFAOYSA-N
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
lysine demethylase 3A Hs Inhibitor Inhibition 7.0 pIC50 - 1
pIC50 7.0 (IC50 1x10-7 M) [1]
lysine demethylase 4C Hs Inhibitor Inhibition 6.2 pIC50 - 1
pIC50 6.2 (IC50 6x10-7 M) [1]
lysine demethylase 6B Hs Inhibitor Inhibition 5.8 pIC50 - 1
pIC50 5.8 (IC50 1.6x10-6 M) [1]
egl-9 family hypoxia inducible factor 1 Hs Inhibitor Inhibition 4.5 pIC50 - 1
pIC50 4.5 (IC50 3.3x10-5 M) [1]