veltuzumab   Click here for help

GtoPdb Ligand ID: 8268

Synonyms: hA20 | IMMU-106
Immunopharmacology Ligand
Compound class: Antibody
Comment: Veltuzumab is a humanized monoclonal antibody targeting CD20. With the exeption of Asp101 in the complementarity-determining region 3 (CDR3) of the antibody's variable heavy chain, its CDRs are identical to rituximab [2]. This single amino acid substitution appears to account for veltuzumab's reduced off-rate compared to rituximab [2] as well as its enhanced capacity to induce antibody-dependent cellular cytotoxicity (ADCC), and complement-mediated cytotoxicity.
Peptide sequence information for this antibody is available from its IMGT/mAb-DB link.
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Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD20 (membrane-spanning 4-domains, subfamily A, member 1) Primary target of this compound Hs Antibody Binding 8.4 pKd - 4
pKd 8.4 (Kd 3.6x10-9 M) [4]