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Synonyms: hA20 | IMMU-106
Compound class: Antibody
Comment: Veltuzumab is a humanized monoclonal antibody targeting CD20. With the exeption of Asp101 in the complementarity-determining region 3 (CDR3) of the antibody's variable heavy chain, its CDRs are identical to rituximab . This single amino acid substitution appears to account for veltuzumab's reduced off-rate compared to rituximab  as well as its enhanced capacity to induce antibody-dependent cellular cytotoxicity (ADCC), and complement-mediated cytotoxicity.
Peptide sequence information for this antibody is available from its IMGT/mAb-DB link.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|An anti-CD20 monoclonal antibody, derived from rituximab.|
|Chronic lymphocytic leukemia||
|FDA and EMA orphan drug for CLL.|
||FDA orphan drug for pemphigus.|