Ligand id: 8394

Name: mithramycin

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 21
Hydrogen bond donors 11
Rotatable bonds 15
Topological polar surface area 358.2
Molecular weight 1084.47
XLogP -0.39
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

Bioactivity Comments
SETDB1-amplified lung cancer cell lines (NCI-H1437 and NCI-H1395) are more sensitive to the growth inhibitory effect of mithramycin than cells without SETDB1 amplification [4].