Synonyms: JNJ 18038683
Compound class:
Synthetic organic
Comment: JNJ-18038683 is a 1:1 mixture of PubChem CID 11151899 and citric acid (2-hydroxypropane-1,2,3-tricarboxylic acid, PubChem CID 311) [1]. We only show the structure for the former moeity which is a selective serotonin 5-HT7 receptor antagonist.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
The supplemental data from Bonaventure et al. (2012) provides pharmacological profile data for JNJ-18038683 across a panel of receptors (incl. serotonin family members, adrenergic, histamine and dopamine receptors) and monoamine neurotransmitter reuptake transporters [1]. The closest affinity compared to that for the 5-HT7 receptor is for the 5-HT6 receptor, with 10-fold selectivity for the former [1]. |
Selectivity at GPCRs | ||||||||||||||||||||||||||||||||||
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