CXCL12β   Click here for help

GtoPdb Ligand ID: 845

Synonyms: SDF-1β | stromal cell-derived factor-1 (SDF-1) | stromal cell-derived factor-1β
Immunopharmacology Ligand
Comment: CXCL12-1α and β were the first isoforms of this chemokine identified. Both proteins contain a signal peptide sequence that medaites their secretion via the canonical intracellular secretory pathway. CXCL12 participates in a variety of processes central to homeostasis and physiology, exerting its biological effects by binding to the chemokine receptors CXCR4 and CXCR7.
Species: Human
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Bioactivity Comments
Gene deletion of CXCL12 in mice is lethal in late stage embryonic development (E18.5) [2]. Lethal developmental defects affecting the central nervous system, heart and vasculature are observed with deletion of the ligand gene, or of the genes for the CXCL12 receptors (CXCR4 [4-5] and CXCR7 [3]).
Natural/Endogenous Targets
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CXCR4 Ligand is endogenous in the given species Hs Agonist Full agonist 7.9 pKd - 1
pKd 7.9 (Kd 1.37x10-8 M) [1]