delta like canonical Notch ligand 4   Click here for help

GtoPdb Ligand ID: 8452

Abbreviated name: DLL4
Comment: DLL4 is a 685 amino acid, peptide Notch receptor ligand expressed on the membranes of vascular endothelial cells [4]. DLL4 is a molecular target for the development of anti-cancer therapies [3].
Species: Human
Other ligands which bind to or alter the activity of this ligand
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Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
demcizumab Peptide Primary target of this compound Hs Antibody Binding 9.5 pKi - 1
pKi 9.5 (Ki 3.3x10-10 M) [1]