SGC707   Click here for help

GtoPdb Ligand ID: 8552

PDB Ligand
Compound class: Synthetic organic
Comment: SGC707 is a cell permeable, potent and selective chemical probe for protein arginine methyltransferase 3 (PRMT3), which allosterically inhibits enzyme activity [1]. This is a compound from the Structural Genomics Consortium's (SGC) Epigenetics Probes Collection.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 74.33
Molecular weight 298.14
XLogP 0.75
No. Lipinski's rules broken 0
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Canonical SMILES O=C(Nc1ccc2c(c1)ccnc2)NCC(=O)N1CCCC1
Isomeric SMILES O=C(Nc1ccc2c(c1)ccnc2)NCC(=O)N1CCCC1
InChI InChI=1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)
Bioactivity Comments
SGC707 is selective for PRMT3 compared to 31 other methyltransferases and >250 non-epigenetic targets [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
protein arginine methyltransferase 3 Primary target of this compound Hs Allosteric modulator Negative 7.3 pKd - 1
pKd 7.3 (Kd 5.3x10-8 M) [1]