begelomab   Click here for help

GtoPdb Ligand ID: 8691

Synonyms: Begendina&rg; (proprietary name) | BT 5/9 | SAND 26
Immunopharmacology Ligand
Compound class: Antibody
Comment: Begelomab is an investigational murine monoclonal antibody targeting DPP4 (dipeptidyl-peptidase 4, a.k.a. CD26 T cell antigen).
Peptide sequence and structural information for begelomab is available from its IMGT/mAb-DB entry.
A search of patent literature reveals that the heavy chain variable region CDRs and light chain variable region CDRs of begelomab match sequences of anti-CD26 antibodies disclosed in FIG 2a of patent EP2767549 A1 [1].
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Bioactivity Comments
EP2767549 A1 [1] does not provide a precise dissociation constant value for any preferred antibodies. In the table below, we present a value which the author suggests would be the desireable affinity of a preferred antibody.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
dipeptidyl peptidase 4 Primary target of this compound Hs Antibody Binding ~10.0 pKd - 1
pKd ~10.0 (Kd ~1x10-10 M) [1]