begelomab   Click here for help

GtoPdb Ligand ID: 8691

Synonyms: Begendina&rg; (proprietary name) | BT 5/9 | SAND 26
Immunopharmacology Ligand
Compound class: Antibody
Comment: Begelomab is an investigational murine monoclonal antibody targeting DPP4 (dipeptidyl-peptidase 4, a.k.a. CD26 T cell antigen).
Peptide sequence and structural information for begelomab is available from its IMGT/mAb-DB entry.
A search of patent literature reveals that the heavy chain variable region CDRs and light chain variable region CDRs of begelomab match sequences of anti-CD26 antibodies disclosed in FIG 2a of patent EP2767549 A1 [1].
Click here for help
1. Di Naro AF. (2014)
Anti-CD26 Antibodies and Uses Thereof.
Patent number: EP2767549 A1. Assignee: Adienne S.A.. Priority date: 19/02/2013. Publication date: 20/08/2014.
2. Hatano R, Ohnuma K, Yamamoto J, Dang NH, Yamada T, Morimoto C. (2013)
Prevention of acute graft-versus-host disease by humanized anti-CD26 monoclonal antibody.
Br J Haematol, 162 (2): 263-77. [PMID:23692598]