angiopoietin-like 3   Click here for help

GtoPdb Ligand ID: 8716

Abbreviated name: ANGPTL3
Comment: ANGPTL3 is prodominantly secreted in the liver, and has a pro-angiogenic function. The mature peptide is 444 amino acids long, and can be cleaved to form two functionally different sub-peptides: an N-terminal coiled-coil domain-containing chain (involved in lipid metabolism) and a C-terminal fibrinogen chain (angiogenic function).
Species: Human
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
evinacumab Peptide Approved drug Primary target of this compound Hs Antibody Binding 8.9 pKd - 1
pKd 8.9 (Kd 1.35x10-9 M) [1]