angiopoietin-like 3   Click here for help

GtoPdb Ligand ID: 8716

Abbreviated name: ANGPTL3
Comment: ANGPTL3 is prodominantly secreted in the liver, and has a pro-angiogenic function. The mature peptide is 444 amino acids long, and can be cleaved to form two functionally different sub-peptides: an N-terminal coiled-coil domain-containing chain (involved in lipid metabolism) and a C-terminal fibrinogen chain (angiogenic function).
Species: Human
1. Sleeman MW, Guasrova V, Murphy AJ. (2015)
Anti-ANGPTL3 antibodies and uses thereof.
Patent number: US9018356 B2. Assignee: Regeneron Pharmaceuticals, Inc.. Priority date: 17/06/2011. Publication date: 28/04/2015.