IGN523   Click here for help

GtoPdb Ligand ID: 8737

Compound class: Antibody
Comment: IGN523 is a humanized anti-CD98 (SLC3A2) monoclonal antibody being investigated as a potential therapy for acute myeloid leukemia (AML) [1-2].
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Bioactivity Comments
The affinity data in the table below is that reported in WO2013078377 A1 for the humanized clone 8-34B H2 L1 clone [2].
Selectivity at transporters
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
4F2hc Primary target of this compound Hs Antibody Binding 8.9 pKd - 2
pKd 8.9 (Kd 1.3x10-9 M) [2]