Ligand id: 8930

Name: istiratumab

Bioactivity Comments
The potency of bispecific MM-141 is superior to that using either monospecific or combination antibody therapies targeting the same receptors [3].
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
erb-b2 receptor tyrosine kinase 3 Hs Antibody Binding >9.0 pKd - 3
pKd >9.0 (Kd <1x10-9 M) [3]
Insulin-like growth factor I receptor Hs Antibody Binding >9.0 pKd - 3
pKd >9.0 (Kd <1x10-9 M) [3]