Synonyms: LY-3009120
Compound class:
Synthetic organic
Comment: LY3009120 is a pan-RAF kinase and RAF dimer inhibitor [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
In a screening assay examining over 170 kinases, LY3009120 inhibited only p38 MAPK, EphA2, EphB4, MAP3K1, FYN, and ZAK with binding affinities less than 100 nM [1]. LY3009120 inhibits BRAFV600E with an IC50 of 5.8nM and BRAFV600E/G468A with an IC50 of 17nM [1]. |
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