timolumab   Click here for help

GtoPdb Ligand ID: 9097

Synonyms: 8c10 | BTT-1023 | BTT1023 | r8c10 | SI-3106 | SI-636
Immunopharmacology Ligand
Compound class: Antibody
Comment: Tmolumab is a fully human anti-AOC3 (amine oxidase copper containing 3, VAP1) monoclonal antibody being investigated for its immunomodulatory action.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. Protein BLAST analysis reveals 100% matches with peptides claimed in patent US7897149, in particular with the recombinant fully human antibody BTT-1023 named therein [1].
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Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
amine oxidase copper containing 3 Primary target of this compound Hs Antibody Binding 9.4 – 9.9 pKd - 1
pKd 9.4 – 9.9 (Kd 3.8x10-10 – 1.3x10-10 M) [1]
Description: Value varies slightly between a time-resolved immunofluorometric assay and real time direct binding assay using a BIACORE® surface plasmon resonance assay.