Ligand id: 9123

Name: caplacizumab

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
The Kd value provided in the interaction table below is that for vWF binding by the wild type 12A2 series nanobody [4]. No Kd value is provided for the humanised 12A2H1 which has identical peptide sequence to caplacizumab (other 12A2 series humanised nanobodies are reported as having Kd values in the range 11-39nM) [4].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
von Willebrand factor Hs Antibody Binding 8.5 pKd - 4
pKd 8.5 (Kd 3.1x10-9 M) [4]