urocortin 1   Click here for help

GtoPdb Ligand ID: 919

Abbreviated name: UCN
Comment: The human UCN sequence differs from mouse and rat sequences at residues 2 and 4 representing asparagine and serine respectively.
Species: Human
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Natural/Endogenous Targets
Target
CRF1 receptor
CRF2 receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CRF2 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 9.0 – 9.6 pKd - 1-2
pKd 9.0 – 9.6 [1-2]
CRF1 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 8.6 – 9.5 pKd - 1-3
pKd 8.6 – 9.5 [1-3]
CRF2 receptor Mm Agonist Full agonist 8.8 pKd - 3
pKd 8.8 [3]
CRF2 receptor Rn Agonist Full agonist 8.7 pKd - 3
pKd 8.7 [3]
Ligand mentioned in the following text fields