IMAB362   Click here for help

GtoPdb Ligand ID: 9209

Compound class: Antibody
Comment: IMAB362 is an investigational, first-in-class monoclonal antibody targeting the cell surface molecule claudin18.2 (CLDN18.2), a pan-cancer drug target [1]. Claudin-18 is a tight-junction protein. Splice variant 2 is reported to be a highly selective cell lineage marker of gastric mucosal cells. CLDN18.2 is retained on malignant transformation and is expressed in a significant proportion of primary gastric cancers and their metastases, and ectopic expression of CLDN18.2 is identified in distinct histologic subtypes of pancreatic (primary tumour and metastases) [2], esophageal, ovarian, and lung tumours [1]. The antibody binds to the first extracellular N-terminal domain which is unique to the CLDN18.2 splice variant [1-2].
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
claudin 18 Primary target of this compound Hs Antibody Binding - - - 1