elezanumab   Click here for help

GtoPdb Ligand ID: 9290

Synonyms: ABT-555 | AE12-1Y-QL
Immunopharmacology Ligand
Compound class: Antibody
Comment: Elezanumab (ABT-555) is a fully human monoclonal antibody targeting repulsive guidance molecule-a (RGMA), in development as a potential therapy for multiple sclerosis (MS).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. BLAST peptide anaylsis reveals identical matches with peptides claimed in patent WO2013112922 [2].
Bioactivity Comments
Functional and preclinical data for antibody AE12-1Y-QL are presented in patent WO2013112922 [2], although no affinity value is provided for antibody-RGMA binding.
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
repulsive guidance molecule BMP co-receptor a Primary target of this compound Hs Antibody Binding - - - 2