Synonyms: compound 2 [PMID: 25565255] | RG-7090 | RO-4917523 | Ro4917523
Compound class:
Synthetic organic
Comment: Basimglurant (RO4917523) is a negative allosteric modulator (NAM) of the glutamate metabotropic receptor 5 (mGlu5) GPCR [1], and is a clinical candidate in development for the treatment of psychiatric diseases. Structurally, basimglurant and CTEP [2] are analogues. CTEP has a notably longer half-life in rodents (49 hours) than basimglurant (~10 hours), so is better suited for rodent studies requiring chronic exposure/treatment.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
Basimglurant (RO4917523) is active in a number of experimental anxiety tests [1]. |
Selectivity at GPCRs | ||||||||||||||||||||||||||||||||||
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