blisibimod   Click here for help

GtoPdb Ligand ID: 9518

Synonyms: A-623 | AGP3 peptibody [5] | AMG 623 | Fc-Agp-3 [1]
Immunopharmacology Ligand
Compound class: Peptide
Comment: Blisibimod is a peptibody fusion containing four BAFF binding domains fused to a human Fc domain. By sequestering circulating BAFF ligand, it acts as a functional antagonist of BAFF interaction with the TACI receptor on B cells.
Peptide sequences and structural information for this peptide are available from its IMGT/mAb-DB entry. The peptide sequence for blisibimod is claimed in Amgen's patent WO2002092620 [5].
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
BAFF {Sp: Human} Peptide Primary target of this compound Hs None Binding 11.4 pKd - 5
pKd 11.4 (Kd 4x10-12 M) [5]
Description: Binding to human AGP3 (=BAFF)