gimsilumab   Click here for help

GtoPdb Ligand ID: 9624

Synonyms: MORAb-022
Immunopharmacology Ligand
Compound class: Antibody
Comment: Gimsilumab (MORAb-022) is an investigational, fully human IgG1 monoclonal antibody being evaluated for its potential in the treatment of multiple inflammatory diseases and cancer. It targets granulocyte-macrophage colony stimulating factor (GM-CSF, CSF2), a growth factor involved in autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis and asthma. In the cancer setting, MORAb-022-mediated blocking of CSF2 produces a pro-immunity microenvironment that leads to tumour tissue death in preclinical studies. Peptide sequences (from the WHO INN submission for gimsilumab) match sequences 8 and 12 from Morphotek Inc. patent WO2007092939 [1], and these sequences belong to monoclonal antibody clone G9 specified in the patent.
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GM-CSF Primary target of this compound Hs Antibody Binding 10.8 – 11.0 pKd - 1
pKd 10.8 – 11.0 (Kd 1.7x10-11 – 1.1x10-11 M) [1]
Description: Binding affinity to recombinant hGM-CSF measured by BIACORE surface plasmon resonance.