rogaratinib   Click here for help

GtoPdb Ligand ID: 9789

Synonyms: BAY-1163877 | BAY1163877 | Example 1 [WO2013087578]
Compound class: Synthetic organic
Comment: Rogaratinib (BAY-1163877) is a FGFR-selective kinase inhibitor that is being investigated for antineoplastic activity. The parent molecular structure is claimed as Example 1 in patent WO2013087578, and the dihydrochloride is claimed as Example 2 [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 135.25
Molecular weight 466.18
XLogP 1.58
No. Lipinski's rules broken 0
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Canonical SMILES COCc1c(CN2CCNC(=O)C2)n2c(c1c1cc3c(s1)c(OC)cc(c3)C)c(N)ncn2
Isomeric SMILES COCc1c(CN2CCNC(=O)C2)n2c(c1c1cc3c(s1)c(OC)cc(c3)C)c(N)ncn2
InChI InChI=1S/C23H26N6O3S/c1-13-6-14-8-18(33-22(14)17(7-13)32-3)20-15(11-31-2)16(9-28-5-4-25-19(30)10-28)29-21(20)23(24)26-12-27-29/h6-8,12H,4-5,9-11H2,1-3H3,(H,25,30)(H2,24,26,27)
Bioactivity Comments
1 μM rogaratinib inhibits mTOR activity by only 8.7% [1].
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
fibroblast growth factor receptor 1 Hs Inhibitor Inhibition 7.9 pKi - 1
pKi 7.9 (Ki 1.22x10-8 M) [1]
Description: At a high ATP level.
fibroblast growth factor receptor 3 Hs Inhibitor Inhibition 7.6 pIC50 - 1
pIC50 7.6 (IC50 2.48x10-8 M) [1]