GtoPdb Ligand ID: 9801

Synonyms: CA170_01519.g57 IgG4P | UCB-7665 | UCB7665
Compound class: Antibody
Comment: Rozanolixizumab is an anti-human FcRn monoclonal antibody that is being developed for potential use in the treatment of IgG-driven autoimmune diseases [1-2].
Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Fc fragment of IgG receptor and transporter Hs Antibody Binding ~8.2 – 8.7 pKd - 1
pKd ~8.2 – 8.7 (Kd ~6x10-9 – 2x10-9 M) [1]
Description: In a cell- based in vitro assay using neutral buffer. Note this affinity range is for the 01519.g57 Fab or PEGylated Fab fragment, not the intact IgG4P antibody.