GtoPdb Ligand ID: 9801

Synonyms: CA170_01519.g57 IgG4P | UCB-7665 | UCB7665
Compound class: Antibody
Comment: Rozanolixizumab is an anti-human FcRn monoclonal antibody that is being developed for potential use in the treatment of IgG-driven autoimmune diseases [1-2].
Immunopharmacology Comments
In a first-in-human clinical trial rozanolixizumab produced sustained dose-dependent reductions in serum IgG concentrations [2].
Immunopharmacology Disease
Disease X-Refs Comment References
Myasthenia gravis Disease Ontology: DOID:437
OMIM: 254200
Orphanet: ORPHA589
Phase 2 clinical candidate for myasthenia gravis- see NCT03052751
Autoimmune thrombocytopenic purpura Disease Ontology: DOID:8924
OMIM: 188030
Orphanet: ORPHA3002
Phase 2 clinical candidate for primary immune thrombocytopenia- see NCT02718716