CFZ533

Ligand id: 9802

Name: CFZ533

Bioactivity Comments
CFZ533 (mAb1) shows no agonist activity in an in vitro assay using isolated human PBMCs, blocks CD40 ligand-mediated PBMC proliferation (IC50 58 ng/ml), inhibits CD40L-mediated TNF-α release from human monocyte derived dendritic cells (IC50 40 ng/ml), and has ADCC activity of < 1% (measuring specific lysis) [1].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD40 Hs Antibody Binding 9.2 pKd - 1
pKd 9.2 (Kd 6.9x10-10 M) [1]
Description: Measured using a Biacore assay.