CFZ533

Ligand id: 9802

Name: CFZ533

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
CFZ533 (mAb1) shows no agonist activity in an in vitro assay using isolated human PBMCs, blocks CD40 ligand-mediated PBMC proliferation (IC50 58 ng/ml), inhibits CD40L-mediated TNF-α release from human monocyte derived dendritic cells (IC50 40 ng/ml), and has ADCC activity of < 1% (measuring specific lysis) [1].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD40 Hs Antibody Binding 9.2 pKd - 1
pKd 9.2 (Kd 6.9x10-10 M) [1]
Description: Measured using a Biacore assay.