- Advanced search
- Immuno Portal
- Malaria Portal
Compound class: Synthetic organic
Comment: Pelubiprofen is a nonsteroidal anti-inflammatory type compound . Structurally it is an aryl propionic acid derivative, like ibuprofen. The INN-defined agent is a racemic mixture of enantiomers. We show the structure without specified stereochemistry to represent the mixture. Pelubiprofen is described as a prodrug of 2-arylpropionic acid with modest selectivity for COX2 .
|Pelubiprofen showed potent analgesic, antiadjuvant arthritis activities, and antipyretic properties in in vivo models . We have been unable to find an inhibitory constant for pelubiprofen's inhibition of the COX enzymes in peer reviewed literature. It's mechanism of action has been defined by biological assays and pharmacological effects in in vivo [1,3-4,6].|