semaphorin 3A   Click here for help

GtoPdb Ligand ID: 9902

Immunopharmacology Ligand
Comment: Semaphorin 3A is a secreted class 3 semaphorin. It is a ligand for neuropilin 1. SEMA3A has an immunoglobulin-like, C2-type domain, a PSI domain and a Sema domain. This peptide is critical for normal neuronal pattern development. Increased SEMA3A expression is reported on some tumour cells [1].
Species: Human
Bioactivity Comments
A loss-of-function mutation in SEMA3A has been identified in a patient with Kallmann syndrome (pubertal failure with congenitally absent or impaired sense of smell) [3]. Note that mice lacking Sema3a expression exhibit a Kallmann-like phenotype.
Natural/Endogenous Targets
neuropilin 1