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Compound class: Endogenous peptide in human, mouse or rat
Comment: Semaphorin 3A is a secreted class 3 semaphorin. It is a ligand for neuropilin 1. SEMA3A has an immunoglobulin-like, C2-type domain, a PSI domain and a Sema domain. This peptide is critical for normal neuronal pattern development. Increased SEMA3A expression is reported on some tumour cells .
|A loss-of-function mutation in SEMA3A has been identified in a patient with Kallmann syndrome (pubertal failure with congenitally absent or impaired sense of smell) . Note that mice lacking Sema3a expression exhibit a Kallmann-like phenotype.|