semaphorin 3A   Click here for help

GtoPdb Ligand ID: 9902

Immunopharmacology Ligand
Comment: Semaphorin 3A is a secreted class 3 semaphorin. It is a ligand for neuropilin 1. SEMA3A has an immunoglobulin-like, C2-type domain, a PSI domain and a Sema domain. This peptide is critical for normal neuronal pattern development. Increased SEMA3A expression is reported on some tumour cells [1].
Species: Human
1. Capparuccia L, Tamagnone L. (2009)
Semaphorin signaling in cancer cells and in cells of the tumor microenvironment--two sides of a coin.
J Cell Sci, 122 (Pt 11): 1723-36. [PMID:19461072]
2. Tang MW, Malvar Fernández B, Newsom SP, van Buul JD, Radstake TRDJ, Baeten DL, Tak PP, Reedquist KA, García S. (2018)
Class 3 semaphorins modulate the invasive capacity of rheumatoid arthritis fibroblast-like synoviocytes.
Rheumatology (Oxford), 57 (5): 909-920. [PMID:29471421]
3. Young J, Metay C, Bouligand J, Tou B, Francou B, Maione L, Tosca L, Sarfati J, Brioude F, Esteva B et al.. (2012)
SEMA3A deletion in a family with Kallmann syndrome validates the role of semaphorin 3A in human puberty and olfactory system development.
Hum Reprod, 27 (5): 1460-5. [PMID:22416012]