lilotomab   

GtoPdb Ligand ID: 9950

Synonyms: Betalutin® | HH1 | tetulomab
Compound class: Antibody
Comment: Lilotomab is an investigational murine anti-CD37 monoclonal antibody [1]. A radioimmunoconjugate version that can be loaded with the beta radiation-emitting isotope lutetium-177 (known as 177Lu-lilotomab satetraxetan, and as the trade name Betalutin) is being evaluated as a novel radioimmunotherapeutic for the treatment of non-Hodgkin lymphoma [2]. Satetraxetan is the name of the radionuclide chelator, and this is a DOTA derivative known as (p-SCN-Bn)-DOTA (PubChem CID 10123265).
Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD37 molecule Hs Antibody Binding 8.6 pKd - 1
pKd 8.6 (Kd 2.7x10-9 M) [1]
Description: Binding affinity to CD37 on Daudi (human Burkitt's lymphoma) cells.