GtoPdb Ligand ID: 9950

Synonyms: Betalutin® | HH1 | tetulomab
Compound class: Antibody
Comment: Lilotomab is an investigational murine anti-CD37 monoclonal antibody [1]. A radioimmunoconjugate version that can be loaded with the beta radiation-emitting isotope lutetium-177 (known as 177Lu-lilotomab satetraxetan, and as the trade name Betalutin) is being evaluated as a novel radioimmunotherapeutic for the treatment of non-Hodgkin lymphoma [2]. Satetraxetan is the name of the radionuclide chelator, and this is a DOTA derivative known as (p-SCN-Bn)-DOTA (PubChem CID 10123265).
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD37 molecule Hs Antibody Binding 8.6 pKd - 1
pKd 8.6 (Kd 2.7x10-9 M) [1]
Description: Binding affinity to CD37 on Daudi (human Burkitt's lymphoma) cells.