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Synonyms: ACT451840 | Actelion-451840
Compound class: Synthetic organic
Comment: ACT-451840 is an investigational antimalarial drug, selected from a new class of compounds identified from a phenotypic screen [2,4]. Chemically it is a piperazine-containing compound.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
|No information available.|
|Summary of Clinical Use|
|ACT-451840 has completed Phase 1 clinical trial in healthy subjects with induced blood stage malaria infection (see NCT02223871) [3,6]. A single 500 mg dose of the drug significantly reduced P. falciparum parasitaemia and cure was achieved in 90% of subjects with six once daily doses of 300 mg .|
|Clinical Trial ID||Title||Type||Source||Comment||References|
|NCT02223871||Effect of ACT-451840 Against Early Plasmodium Falciparum Blood Stage Infection in Healthy Subjects||Phase 1 Interventional||Idorsia Pharmaceuticals Ltd.|
|ACT-451840 has a half-life of approximately 34 hours .|