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Abbreviated name: E2
Synonyms: estrogen | oestrodiol | oestrogen
17β-estradiol is an approved drug (FDA (1954, prior history unavailable))
Compound class: Metabolite or derivative
Comment: 17β-estradiol is the predominant form of circulating estrogen and is the endogenous agonist of the estrogen receptor α. In pre-menopausal women 17β-estradiol is mainly produced by the ovaries and placenta and is produced by adipose tissue in men and postmenopausal women.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: estradiol
|No information available.|
|Summary of Clinical Use|
|Estradiol is used to treat unwanted post-menopausal symptoms associated with atrophy of the vagina and/or lower urinary tract.
Drug formulations may contain estradiol valerate.
|Mechanism Of Action and Pharmacodynamic Effects|
|Estradiol bound to its receptor acst as a transcription factor, regulating target gene transcription and protein synthesis.|