Abbreviated name: E2
Synonyms: estrogen | oestrodiol | oestrogen
17β-estradiol is an approved drug (FDA (1954, prior history unavailable))
Compound class:
Metabolite
Comment: 17β-estradiol is the predominant form of circulating estrogen and is the endogenous agonist of the estrogen receptor α. In pre-menopausal women 17β-estradiol is mainly produced by the ovaries and placenta and is produced by adipose tissue in men and postmenopausal women.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: estradiol |
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Natural/Endogenous Targets | |||||
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Selectivity at GPCRs | ||||||||||||||||||||||||||||||||||
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Selectivity at ion channels | ||||||||||||||||||||||||||||||||||
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Selectivity at nuclear hormone receptors | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Selectivity at transporters | ||||||||||||||||||||||||||||||||||
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Targets where the ligand is described in the comment field | |
Target | Comment |
CYP19A1 | Converts androstenedione and testosterone to estrone and 17β-estradiol, respectively. |
Ligand mentioned in the following text fields |
3C. 3-Ketosteroid receptors overview |
Steroid hormone receptors overview |
Maxi chloride channel comments |