baclofen   Click here for help

GtoPdb Ligand ID: 1084

Synonyms: Baclon® | Kemstro® | Lioresal®
Approved drug
baclofen is an approved drug (FDA (2007))
Compound class: Synthetic organic
Comment: The approved drug baclofen is a racemic mixture of two enantiomers; (R)-baclofen and (S)-baclofen. We show the non-stereo structure to represent the mixture.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 63.32
Molecular weight 213.06
XLogP 1.33
No. Lipinski's rules broken 0
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Canonical SMILES NCC(c1ccc(cc1)Cl)CC(=O)O
Isomeric SMILES NCC(c1ccc(cc1)Cl)CC(=O)O
InChI InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
No information available.
Summary of Clinical Use Click here for help
This skeletal muscle relaxant is used to reduce the frequency of muscle spasms and muscle spasticity associated with spinal chord injury.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Baclofen is a GABAB receptor agonist. Activation of these receptors produces baclofen's range of therapeutic actions.