relebactam   Click here for help

GtoPdb Ligand ID: 10852

Synonyms: MK-7655 | MK-7655A | MK7655
Approved drug
relebactam is an approved drug (FDA (2019), EMA (2020))
Compound class: Synthetic organic
Comment: Relebactam is a β-lactamase inhibitor [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 136.66
Molecular weight 348.11
XLogP -2.53
No. Lipinski's rules broken 0
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Canonical SMILES O=C([C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O)NC1CCNCC1
Isomeric SMILES O=C([C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O)NC1CCNCC1
InChI InChI=1S/C12H20N4O6S/c17-11(14-8-3-5-13-6-4-8)10-2-1-9-7-15(10)12(18)16(9)22-23(19,20)21/h8-10,13H,1-7H2,(H,14,17)(H,19,20,21)/t9-,10+/m1/s1
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Summary of Clinical Use Click here for help
Relebactam is currently available for use in the clinic in a combination product which includes imipenem and cilastatin, called Recarbrio®.
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